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Small-molecule administration After shaving the backs of 7-week-old C57 mice, 100 μl of 400 μM KYP-2047 (T8657, Taojiao, China), 8 mM SMER28 (T3155, Taojiao, China), 200 μM Pennogenin 3-O-beta-chacotrioside (T8166, Taojiao, China), or dimethyl sulfoxide (BS087-100 ml, Biosharp, China) was applied to the lower left part of the back of the mice