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Additionally, it has demonstrated efficacy in inhibiting α-synuclein aggregation, a pathological hallmark of PD, further underscoring its potential role in neuroprotection ( However, quercetin’s therapeutic application is challenged by its classification as a Biopharmaceutical Classification System (BCS) Class IV compound, signifying poor solubility and permeability, which limits its bioavailability and clinical effectiveness (Sirvi et al., 2022)

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